4.4 Article

Intramolecular Heck reaction of 2- and 3-iodoindole derivatives for the synthesis of β- and γ-carbolinones

Journal

TETRAHEDRON
Volume 58, Issue 33, Pages 6673-6678

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4020(02)00688-9

Keywords

Heck reaction; Pd catalyst; intramolecular cyclization; indoles; carbolines

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A new synthesis of beta- and gamma-carbolinone derivatives was achieved by an intramolecular Heck cyclisation from the corresponding 3-iodo-1H-indole-2-carboxylic acid allyl-amides 8 and 2-iodo-1H-indole-3-carboxylic acid allyl-amides 9. (C) 2002 Elsevier Science Ltd. All rights reserved.

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