Journal
NEURON
Volume 35, Issue 4, Pages 643-656Publisher
CELL PRESS
DOI: 10.1016/S0896-6273(02)00825-5
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Funding
- NCI NIH HHS [CA46592] Funding Source: Medline
- NIAMS NIH HHS [P30 AR48310, AR20557] Funding Source: Medline
- NIDDK NIH HHS [5P60-DK20572] Funding Source: Medline
- NINDS NIH HHS [R01 NS040750-01, R01 NS40750-01] Funding Source: Medline
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Stem cells in different regions of the nervous system give rise to different types of mature cells. This diversity is assumed to arise in response to local environmental differences, but the contribution of cell-intrinsic differences between stem cells has been unclear. At embryonic day (E)14, neural crest stem cells (NCSCs) undergo primarily neurogenesis in the gut but gliogenesis in nerves. Yet gliogenic and neurogenic factors are expressed in both locations. NCSCs isolated by flow-cytometry from E14 sciatic nerve and gut exhibited heritable, cell-intrinsic differences in their responsiveness to lineage determination factors. Gut NCSCs were more responsive to neurogenic factors, while sciatic nerve NCSCs were more responsive to gliogenic factors. Upon transplantation of uncultured NCSCs into developing peripheral nerves in vivo, sciatic nerve NCSCs gave rise only to glia, while gut NCSCs gave rise primarily to neurons. Thus, cell fate in the nerve was stem cell determined.
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