Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 33, Issue 4, Pages 450-456Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0891-5849(02)00818-3
Keywords
free radicals; 8-hydroxy-dG; 2-hydroxy-dATP; MTH1
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Since the discovery of 8-OH-dG formation, various aspects of oxidative DNA damage have been studied. For example, 2-OH-dA and a glyoxal-dG adduct were discovered as new types of oxidative DNA damage; 2-OH-dATP was found to induce mutations and to be a good substrate of a nucleotide sanitization enzyme, the MTHI protein; and efforts were continued to establish standard methodologies for 8-OH-dG analyses in urine and cellular DNA. By these studies, we found solid chemistry-based approaches were often useful to clarify the biological phenomena. (C) 2002 Elsevier Science Inc.
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