Journal
NEUROSCIENCE LETTERS
Volume 328, Issue 3, Pages 233-236Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(02)00519-0
Keywords
emotional learning; Pavlovian conditioning; psychopathy; social phobia; functional magnetic resonance imaging; skin conductance
Categories
Ask authors/readers for more resources
While psychopaths (PP) lack anticipatory fear, social phobics (SP) are characterized by excessive fear. Criminal PP, SP and healthy controls (HC) participated in differential aversive delay conditioning with neutral faces as conditioned (CS) and painful pressure as unconditioned stimuli. Functional magnetic resonance imaging revealed differential activation in the limbic-prefrontal circuit (orbitofrontal cortex, insula, anterior cingulate, amygdala) in the HC. By contrast, the PP displayed brief amygdala, but no further brain activation. The SIP showed increased activity to the faces in the amygdala and orbitofrontal cortex already during habituation. Thus, a hypoactive frontolimbic circuit may represent the neural correlate of psychopathic behavior, whereas an overactive frontolimbic system may underly social fear. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available