Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 277, Issue 33, Pages 29983-29991Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M112121200
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We describe a new human isoform, GFAPepsilon, of the intermediary filament protein GFAP (glial fibrillary acidic protein). GFAPepsilon mRNA is the result of alternative splicing and a new polyadenylation signal, and thus GFAPepsilon has a new C-terminal protein sequence. This provides GFAPepsilon with the capacity for specific binding of presenilin proteins in yeast and in vitro. Our observations suggest a direct link between the presenilins and the cytoskeleton where GFAPepsilon is incorporated. Mutations in GFAP and presenilins are associated with Alexander disease and Alzheimer's disease, respectively. Accordingly, GFAPepsilon should be taken into consideration when studying neurodegenerative diseases.
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