Journal
SCIENCE
Volume 297, Issue 5584, Pages 1193-1196Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1071362
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Funding
- NCI NIH HHS [CA46128] Funding Source: Medline
- NINDS NIH HHS [NS36251] Funding Source: Medline
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In striated muscle, the plasma membrane forms tubular invaginations (transverse tubules or T-tubules) that function in depolarization-contraction coupling. Caveolin-3 and amphiphysin were implicated in their biogenesis. Amphiphysin isoforms have a putative role in membrane deformation at endocytic sites. An isoform of amphiphysin 2 concentrated at T-tubules induced tubular plasma membrane invaginations when expressed in nonmuscle cells. This property required exon 10, a phosphoinositide-binding module. In developing myotubes, amphiphysin 2 and caveolin-3 segregated in tubular and vesicular portions of the T-tubule system, respectively. These findings support a role of the bilayer-deforming properties of amphiphysin at T-tubules and, more generally, a physiological role of amphiphysin in membrane deformation.
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