Journal
BRAIN RESEARCH
Volume 946, Issue 2, Pages 307-313Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(02)03041-X
Keywords
insulin-like growth factor-I (IGF-I); IGF-I receptor; aging; cerebral cortex; hippocampus; immunohistochemistry
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In the present study, we investigated age-related changes in IGF-I receptor localization in the cerebral cortex and hippocampus of Sprague-Dawley rats using immunohistochemistry. In the cerebral cortex of adult rats, weakly stained cells were seen in layers II-III and layer V/VI in several cortical regions. In aged rats, there was a significant increase in IGF-I receptor immunoreactivity in the pyramidal cells in the same cortical regions. In the hippocampus of adult rats, several moderately stained neurons were seen in CA1-3 areas and the dentate gyrus. Levels of IGF-I receptor protein increased substantially with age in the CA3 area of the hippocampus. Our first morphological data concerning the differential regulation of IGF-I receptors in aged cerebral cortex and hippocampus may provide insights into age-related changes in trophic support as well as basic knowledge required for the study of neurodegenerative diseases such as Alzheimer's disease. (C) 2002 Elsevier Science B.V. All rights reserved.
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