Journal
NEUROSCIENCE LETTERS
Volume 328, Issue 3, Pages 273-276Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3940(02)00547-5
Keywords
Alzheimer's disease; cathepsin D; genetics; apolipoprotein E; polymorphism
Categories
Funding
- Telethon [E.0980] Funding Source: Medline
Ask authors/readers for more resources
A recent study has shown that a genetic variation in the Cathepsin D (catD) gene is a major risk factor for the development of Alzheimer's disease (AD). CatD is an intracellular aspartyl protease involved in neurodegeneration. A C --> T (Ala --> Val) transition at position 224 has been associated with altered intracellular maturation. Recently, a significant overrepresentation of the T allele of the catD gene in AD patients compared with controls was reported. However, this finding has not yet been confirmed. We analyzed the distribution of catD and apolipoprotein E polymorphisms in Italian patients with sporadic and familial AD (FAD). Our studies revealed that the distribution of catD polymorphism did not differ in AD and FAD patients and controls. Thus, our data do not support a role for the catD gene as a genetic risk factor in the development of AD. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available