4.5 Article

Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 12, Issue 16, Pages 2197-2200

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PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(02)00363-3

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A novel class of small molecule human granzyme B inhibitors is reported. Compound 20 has a K-i of 7 nM against human granzyme B and blocks CTL mediated apoptosis with an IC50 of 3 micromolar. (C) 2002 Elsevier Science Ltd. All rights reserved.

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