Journal
BIOTECHNOLOGY AND BIOENGINEERING
Volume 79, Issue 4, Pages 465-471Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/bit.10299
Keywords
bactericidal; antibacterial; polycation; surface derivatization; nanocoating; synthetic polymers
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A facile methodology has been developed for covalently derivatizing the surfaces of common materials with a designed antibacterial polycation, poly(vinyl-pyridinium bromide), wherein the first, key step involves surface coating with a nanolayer of silica. Various commercial synthetic polymers derivatized in this manner become bactericidal-they kill up to 99% of deposited, from either an aerosol or an aqueous suspension, Gram-positive and Gram-negative bacteria on contact. (C) 2002 Wiley Periodicals, Inc.
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