4.7 Article Proceedings Paper

Mechanical strength of microcapsules made of different wall materials

Journal

INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 242, Issue 1-2, Pages 307-311

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-5173(02)00193-X

Keywords

microcapsules; mechanical strength; micromanipulation; melamine; formaldehyde; urea-formaldehyde; gelatin

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The mechanical strength of microcapsules made of three different wall materials, including melamine-formaldehyde resin, urea-formaldehyde resin and gelatin-gum arabic coacervate, were measured by a micromanipulation technique. Single microcapsules were compressed to large deformations or rupture and the force being imposed on them were measured simultaneously. Melamine-formaldehyde and urea-formaldehyde microcapsules showed clear bursting under compression, and their bursting force, deformation at bursting and deformation at a pesudo yield point were determined. Gelatin microcapsules did not show clear bursting under compression, and their mechanical strength was characterized by the force required to cause their deformation to 50%. The mechanical strengths of these three types of microcapsules are compared in this paper. (C) 2002 Elsevier Science B.V. All rights reserved.

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