Journal
ONCOGENE
Volume 21, Issue 37, Pages 5765-5772Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1205702
Keywords
EMMPRIN; MMP2; phospholipase A(2); 5-lipoxygenase; breast cancer cell; fibroblast
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Metalloproteinases (NIMP) produced by both cancer and normal stromal fibroblast cells play a critical role in the metastatic spread of tumours, however little is known of the regulation of their release. In this report we demonstrate that breast cancer cells in culture release apparently full length soluble EMMPRIN that promotes the release of pro-MMP2 from fibroblasts. The generation of MMP2 is mediated by activation of phospholipase A(2) and 5-lipoxygenase. These results suggest that the production of soluble EMMPRIN, phospholipase A(2) and 5-lipoxygenase activities are sites for potential therapeutic intervention.
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