Journal
ORGANIC LETTERS
Volume 4, Issue 17, Pages 2845-2848Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol020104+
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[GRAPHIC] Azaspirene isolated from the fungus Neosartorya sp. is a novel angiogenesis inhibitor with a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione skeleton. Azaspirene inhibits the endothelial migration induced by vascular endothelial growth factor (ED100 = 27.1 muM).
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