Journal
CELL
Volume 110, Issue 4, Pages 467-478Publisher
CELL PRESS
DOI: 10.1016/S0092-8674(02)00824-3
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Funding
- NCI NIH HHS [CA87691] Funding Source: Medline
- NEI NIH HHS [EY11632] Funding Source: Medline
- NIGMS NIH HHS [GM61672] Funding Source: Medline
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The number of cells in an organism is determined by regulating both cell proliferation and cell death. Relatively few mechanisms have been identified that can modulate both of these processes. In a screen for Drosophila mutations that result in tissue overgrowth, we identified salvador (sav), a gene that promotes both cell cycle exit and cell death. Elevated Cyclin E and DIAP1 levels are found in mutant cells, resulting in delayed cell cycle exit and impaired apoptosis. Salvador contains two WW domains and binds to the Warts (or LATS) protein kinase. The human ortholog of salvador(hWW45) is mutated in three cancer cell lines. Thus, salvador restricts cell numbers in vivo by functioning as a dual regulator of cell proliferation and apoptosis.
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