Short-term treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failure

The present study assesses whether ranolazine increases left ventricular (LV) function without an increase in myocardial oxygen consumption (M(V) over dot o(2)) and thus improves LV mechanical efficiency in dogs with heart failure (HF). Ranolazine did not change M(V) over dot O-2 and LV mechanical efficiency increased (22.4+/-2.8% to 30.9+/-3.4% (P<0.05). In contrast, dobutamine significantly increased M(V) over dot O-2 and did not improve mechanical efficiency. Thus, short-term treatment with ranolazine improved LV function without an increase in M(V) over dot O-2, resulting in an increased myocardial mechanical efficiency in dogs with HF.