Journal
NEUROSCIENCE LETTERS
Volume 329, Issue 1, Pages 111-115Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(02)00589-X
Keywords
Alzheimer's disease; beta-amyloid; microglia; adhesion molecule; immunocytochemistry; inflammation; transgenic mouse brain
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To study the relationship of beta-amyloid-mediated micro- and astrogliosis and inflammation-induced proteins including intercellular adhesion molecule (ICAM-1), brain tissue from transgenic Tg2576 mice expressing the Swedish mutation of the human amyloid precursor protein were examined for ICAM-1 expression. Immunocytochemistry demonstrated a diffuse immunostaining of ICAM-1 in the corona around fibrillary beta-amyloid plaques and an upregulation of ICAM-1 in activated microglial cells located in close proximity to the plaques, an ICAM-1 distribution pattern that partly mimics the situation in the brain of Alzheimer patients. The developmental time course revealed that the rate of cortical ICAM-1 induction was somewhat behind that of the progression of beta-amyloid plaque deposition. The microglial expression of ICAM-1 is a further indicator of the presence of inflammatory reactions in aged transgenic Tg2576 mouse brain, and may be a result of plaque-mediated astrocytic interleukin-1beta upregulation. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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