Journal
DEVELOPMENTAL BRAIN RESEARCH
Volume 137, Issue 2, Pages 135-138Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-3806(02)00436-4
Keywords
motor hyperactivity; 6-hydroxydopamine; 5-hydroxytryptamine (5-HT) transporter; caudate-putamen; nucleus accumbens; development
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Funding
- NIMH NIH HHS [MH-34006, MH-47370] Funding Source: Medline
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We examined serotonin (5-HT) transporters in rat forebrain using quantitative autoradiography at three distinct developmental stages after neonatal 6-hydroxydopamine lesions. The lesions substantially increased 5-HT transporter binding in both caudate-putamen and nucleus accumbens, but not cerebral cortex. The effects reached maximal levels as early as postnatal day (PD) 24, and were sustained until early adulthood. Behavioral analyses indicated that neonatal lesions resulted in motor hyperactivity on PD 24, but not on PD 36 or 59. These findings suggest that excess 5-HT transporters reflect serotonin hyperinnervation reported to occur in lesioned rats, and may modulate motor hyperactivity. (C) 2002 Elsevier Science B.V. All rights reserved.
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