Journal
MARINE ENVIRONMENTAL RESEARCH
Volume 54, Issue 3-5, Pages 357-360Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0141-1136(02)00114-9
Keywords
amphipod; metallothionein; lipid peroxidation; copper; detoxitication; Gammarus locusta; biomarker
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The aim of the current work was to determine over 10 days the effects of water-borne exposure of the marine amphipod Gammarus locusta to 4 mugCu 1(-1) on the metallothionein (NIT; measured by differential pulse polarography) protection system and lipid peroxidation (LP; thiobarbituric acid-reactive malondialdehyde equivalents) as a measure of oxidative damage. MT levels in exposed animals increased significantly at day 2 (36% > control; P < 0.001) and remained high at days 6 and 10 (55 and 38%, respectively, P < 0.001). The maximum level of NIT at day 6 coincided with the highest Cu body-burden. LP increased within 1 day of exposure, indicative of Cu as an oxidative stressor. However, in contrast to NIT, the highest LP level was seen at day 4 (68% > control, P < 0.001) before returning to control values by day 6, indicating a protective role of NIT against the pro-oxidant effects of Cu. (C) 2002 Elsevier Science Ltd. All rights reserved.
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