4.4 Article

Alterations of acute phase reaction and cytokine production in patients following severe burn injury

Journal

BURNS
Volume 28, Issue 6, Pages 535-542

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/S0305-4179(02)00050-5

Keywords

burn injury; cytokines; procalcitonin; SIRS; MODS

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To determine the acute immunologic reaction, mediated by cytokines, interleukines (lLs) and growth factors and the susceptibility to infections and sepsis after severe burn injury a prospective, single unit, longitudinal study of acute phase. reactants and mediators who performed. After approval by the ethics committee of our hospital, we investigated the plasma concentrations of IL-2,-6,-8, -10, and -13, the soluble IL-2 receptor (sIL-2R), and the acute phase proteins procalcitonin (PCT) and C-reactive protein (CRP) at admission and every 3 days in 24 patients over a time course of 28 days after thermal injury and categorized by percent burn: less than or equal to30% (group 1; n = 12) and >30% (group 2;n = 12). Shortly after burn injury we found higher concentrations of IL-2, -6, -10 and PCT in those patients >30% TBSA. During the study period, we found significant higher levels of acute phase proteins, IL-6 and -8 in patients >30% TBSA. The incidence of SIRS and MODS was three times increased in patients >30% TBSA. Our results show different patterns of cytokines and acute phase proteins in patients with different burned surface areas over a long time and continuous monitoring of a more distinct inflammatory response in these patients. (C) 2002 Elsevier Science Ltd and ISBI. All rights reserved.

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