Journal
JOURNAL OF NEUROLOGY
Volume 249, Issue 9, Pages 1246-1249Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00415-002-0820-3
Keywords
amyotrophic lateral sclerosis; autonomic dysfunction botulinum toxin A; salivary glands
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Recent studies have revealed autonomic dysfunction in amyotrophic lateral sclerosis (ALS). We studied salivary gland function by quantitative scintigraphy in ALS patients (n = 30) and healthy controls (n = 30). Uptake of Tc-99m-pertechnetate in the parotid and submandibular glands was significantly decreased in ALS patients. No correlation was found between radiotracer uptake and regions of onset (bulbar-limb), duration of disease, or functional scores. Our data show early subclinical autonomic involvement supporting the view that ALS is a multisystem degenerative disease.
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