Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 20, Issue 3, Pages 227-229Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0924-8579(02)00159-0
Keywords
synergism; acetyldihydropyridines; antibiotics; resistance modifiers; E. coli
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Eleven analogues of nifedipine (NP) showed synergistic interactions with ampicillin (Ap) and erythromycin (Er) on Escherichia coli K12LE140/F'lac. The antibacterial effect of Ap was enhanced by most analogues but compound (G9) and (+/-)-vekapamil (VP) were antagonistic. Two of the 11 compounds (G7, G8) were synergistic with Er and four were additive. With a sensitive clinical isolate of E. coli Gy-1/Ap(sens)Er(res), compound G1 antagonized the antibacterial effect of Ap and a synergistic effect was found in the combination of Er with G4, G5, G6 or G7. None of the drugs had any effect on a multidrug resistant (MDR) clinical isolate of E. coli Gy-2/Ap(res)Er(res). (C) 2002 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.
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