Journal
PERSPECTIVES IN BIOLOGY AND MEDICINE
Volume 45, Issue 4, Pages 549-568Publisher
JOHNS HOPKINS UNIV PRESS
DOI: 10.1353/pbm.2002.0070
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The freedom of a doctor to treat an individual patient in the way he believes best has been markedly limited by the concept of evidence-based medicine. Clearly all would wish to practice according to the best available evidence, but it has become accepted that evidence-based means that which is derived from randomized, and preferably double-blind, clinical trials. The history of clinical trial development, which can be traced to the use of oranges and lemons for the treatment of scurvy ill 1747, has reflected a progressive need to establish whether smaller and smaller effects of treatment are real. It has led to difficult concepts such as equivalence and aberrations such as meta-analysis. An examination of evidence-based practice shows that it has usually been filtered through the opinions of experts and journal editors, and opinion-based medicine would be a more appropriate term. In the real world of individual patients with multiple diseases who are receiving a number of different drugs, the practice of evidence-based (or even opinion-based) medicine is extremely difficult. For each patient a judgment has to be made by the clinician of the likely balance of risks and benefits of any therapy. Good practice still requires clinical freedom for doctors.
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