Journal
JOURNAL OF HETEROCYCLIC CHEMISTRY
Volume 39, Issue 5, Pages 1019-1024Publisher
WILEY-BLACKWELL
DOI: 10.1002/jhet.5570390525
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A novel method for synthesis of polysubstituted pyrrolidines, which possess a C-2 stereocenter, was developed. The strategy involves Grignard addition to the succinimide, derived from L-tartaric acid, followed by stereocontrolled triethylsilane promoted reduction of the resulting cyclic amidols.
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