Journal
JOURNAL OF NEUROCHEMISTRY
Volume 82, Issue 6, Pages 1566-1569Publisher
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1471-4159.2002.01146.x
Keywords
arretin; myelin inhibitors; nerve regeneration; neurite outgrowth; OMgp
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A protein fraction purified from bovine brain myelin, previously called arretin because of its ability to inhibit neurite outgrowth, has been identified as consisting predominantly of oligodendrocyte-myelin glycoprotein (OMgp). We show that it is a potent inhibitor of neurite outgrowth from rat cerebellar granule and hippocampal cells; from dorsal root ganglion explants in which growth cone collapse was observed; from rat retinal ganglion neurons; and from NG108 and PC12 cells. OMgp purified by a different procedure from both mouse and human myelin behaves identically in all bioassays tested.
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