Journal
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
Volume 37, Issue 9, Pages 1108-1110Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/003655202320378338
Keywords
cytokines; extra-intestinal inflammatory bowel disease; skin lesion
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Eight patients with pyoderma gangrenosum associated with Crohn disease were treated with infliximab. All had active mucosal inflammation indicated by endoscopic examination. Within 1-4 months, infliximab treatment resulted in complete healing of the pyoderma gangrenosum in 3 cases (1 parastomal, 2 lower limb), partial healing in 3 (2 parastomal, 1 lower limb) and temporary improvement in 2. Adverse effects such as skin rash, pneumonia and diarrhoea were seen in three patients. Our results imply that infliximab has a therapeutic potential on skin manifestations associated with inflammatory bowel disease, even though successful treatment may require repeat courses of infliximab infusions.
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