Journal
JOURNAL OF MEDICAL ENTOMOLOGY
Volume 39, Issue 5, Pages 736-741Publisher
ENTOMOL SOC AMER
DOI: 10.1603/0022-2585-39.5.736
Keywords
Eucalyptus citriodora; p-methane-3,8-diol; stereoisomers; Anopheles gambiae s.s
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Funding
- PHS HHS [U19A145511-01] Funding Source: Medline
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Four stereoisomers; of p-menthane-3,8-diol, which make Lip the natural product obtained from Eucalyptus citriodora, were synthesized through stereoselective procedures. Repellency assays showed that all the four were equally active against Anopheles gambiae s.s. Racemic blends and the diastereoisomeric mixture of all the four isomers were also equally repellent. 1-alpha-terpeneol, with a single hydroxyl function at C-8 and unsaturation at C-8, and menthol, with a single hydroxyl function at C-3, were not repellent. The practical implication of these results is discussed.
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