Journal
MOLECULAR AND CELLULAR BIOCHEMISTRY
Volume 238, Issue 1-2, Pages 105-110Publisher
SPRINGER
DOI: 10.1023/A:1019963222510
Keywords
nuclear factor kappa B; amentoflavone; peroxisome proliferator-activated receptor gamma; cyclooxygenase-2; translocation; signal transduction
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Amentoflavone, a biflavonoid with antiinflammatory activity, downregulates COX-2 expression in TNFalpha-activated A549 cells with concomitant inhibition of NF-kappaB mediated signaling cascades. We demonstrate here that amentoflavone inhibits NF-kappaB/DNA binding activity potently along with inhibition of degradation of IkappaBalpha and NF-kappaB translocation into nucleus in TNFalpha-activated A549 cells. This flavonoid upregulates PPAR gamma, a transcription factor involved in repressing many cytokine-induced gene expressions. Hence amentoflavone, a dietary constituent, may be of therapeutic value for several lung diseases where COX-2 plays an important role.
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