Journal
CELL DEATH AND DIFFERENTIATION
Volume 9, Issue 9, Pages 873-880Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.cdd.4401093
Keywords
autophagy; epsilon(gamma-glutamyl)lysine crosslinks; Huntingtin; neurodegeneration; nuclear inclusions
Categories
Ask authors/readers for more resources
By crossing Huntington's disease (HD) R6/1 transgenic mice with 'tissue' transglutaminase (TG2) knock-out mice, we have demonstrated that this multifunctional enzyme plays an important role in the neuronal death characterising this disorder in vivo. In fact, a large reduction in cell death is observed in R6/1, TG2(-/-) compared with R6/1 transgenic mice. In addition, we have shown that the formation of neuronal intranuclear inclusions (NII) is potentiated in absence of the 'tissue' transglutaminase. These phenomena are paralleled by a significant improvement both in motor performances and survival of R6/1, TG2 (-/-) versusR1/1 mice. Taken together these findings suggest an important role for tissue transglutaminase in the regulation of neuronal cell death occurring in Huntington's disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available