Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 66, Issue 9, Pages 1963-1966Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.66.1963
Keywords
cytokine; macrophage; Lactobacillus; inflammation; probiotics
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Eleven strains of lactobacilli were tested for their ability to induce the murine macrophage-like cell line J774.1 to secrete cytokines. Some of the bacteria tested induce the production of interleukin(IL) 6, IL-12, and tumor necrosis factor alpha (TNF-alpha) by J774.1 cells. Seven strains also induced the production of IL-10. However, no IL-1beta was produced. Lactobacillus acidophilus TMC 0356 significantly induced the production of more IL-6, IL-10, IL-12, and TNF-alpha than the other bacteria tested (p < 0.0001; ANOVA). These results suggest that lactobacilli can activate macrophages to secrete both inflammatory and antiinflammatory cytokines. Selected strains might be used to bring about pro or antiinflammatory immune reactions.
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