Journal
TRENDS IN BIOTECHNOLOGY
Volume 20, Issue 9, Pages 395-401Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0167-7799(02)02022-X
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Semisynthetic DNA-protein conjugates, generated by either covalent or non-covalent coupling chemistry, are versatile molecular tools applicable in bioanalytical and synthetic chemical procedures. This article reviews the synthesis and characterization of artificial nucleic acid-protein conjugates, in addition to applications arising in the life sciences and nanobiotechnology, such as the self-assembly of high-affinity reagents for immunological detection assays and biosensors, the fabrication of laterally microstructured biochips, and the biomimetic 'bottom-up' synthesis of nanostructured supramolecular devices.
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