Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 3, Issue 9, Pages 710-718Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm911
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Since the discovery in 1957 that cyclic AMP acts as a second messenger for the hormone adrenaline, interest in this molecule and its companion, cyclic GMP, has grown. Over a period of nearly 50 years, research into second messengers has provided a framework for understanding transmembrane signal transduction, receptor-effector coupling, protein-kinase cascades and downregulation of drug responsiveness. The breadth and impact of this work is reflected by five different Nobel prizes.
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