Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 46, Issue 9, Pages 3039-3041Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.46.9.3039-3041.2002
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Funding
- NCRR NIH HHS [M01 RR001346, M01-RR-01346] Funding Source: Medline
- NIDCR NIH HHS [R01 DE011381, 5 R01 DE11381] Funding Source: Medline
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The interaction between caspofungin acetate and voriconazole was studied in vitro by using 48 clinical Aspergillus spp. isolates obtained from patients with invasive aspergillosis. MICs were determined by the NCCLS broth microdilution method. Synergy, defined as a fractional inhibitory concentration (FIC) index of < 1, was detected in 87.5% of the interactions; an additive effect, defined as an FIC index of 1.0, was observed in 4.2% of the interactions; and a subadditive effect, defined as an FIC index of 1.0 to 2.0, was found in 8.3% of the interactions. No antagonism was observed. Animal models are required to validate the in vivo significance of these in vitro data presented for the combination of caspofungin and voriconazole.
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