Journal
GENES & DEVELOPMENT
Volume 16, Issue 17, Pages 2225-2230Publisher
COLD SPRING HARBOR LAB PRESS
DOI: 10.1101/gad.1014902
Keywords
histone; methylation; mitosis; PR-Set7
Categories
Funding
- NIGMS NIH HHS [R01 GM037120, GM-53512, F32 GM064279, R37 GM053512, R37 GM037120, GM-64279] Funding Source: Medline
Ask authors/readers for more resources
We describe distinct patterns of histone methylation during human cell cycle progression. Histone H4 methyltransferase activity was found to be cell cycle-regulated, consistent with increased H4 Lys 20 methylation at mitosis. This increase closely followed the cell cycle-regulated expression of the H4 Lys 20 methyltransferase, PR-Set7. Localization of PR-Set7 to mitotic chromosomes and subsequent increase in H4 Lys 20 methylation were inversely correlated to transient H4 Lys 16 acetylation in early S-phase. These data suggest that H4 Lys 20 methylation by PR-Set7 during mitosis acts to antagonize H4 Lys 16 acetylation and to establish a mechanism by which this mark is epigenetically transmitted.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available