Journal
JOURNAL OF GASTROINTESTINAL SURGERY
Volume 6, Issue 5, Pages 664-670Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S1091-255X(02)00044-6
Keywords
carcinoid tumor; embolization; combined modality therapy; gastrointestinal neoplasms; liver neoplasms; survival rate; quality of life
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Hepatic artery embolization (HAE) has been utilized for treatment of advanced hepatic carcinoid metastases, with promising symptom palliation and tumor control. Our institution employs transcatheter HAE using Lipiodol/Gelfoam for treatment of carcinoid hepatic metastases, and this report presents our experience with twenty-four patients, examining symptom control, quality-of-life, octreotide dependence, and tumor progression. Twenty-four (11 male, 13 female, mean age=59.4+/-2.5 yr) patients with carcinoid and unresectable hepatic metastases, confirmed by urinary 5-hydroxyindole acetic acid (5-HIAA) measurement and biopsy, were treated with Lipiodol/Gelfoam HAE from 1993-2001. Median follow-up was 35.0 months. Before HAE, 14 patients (58.3%) had malignant carcinoid syndrome, with symptoms quantified using our previously reported Carcinoid Symptom Severity Score, and 13 patients (54.2%) required octreotide for symptom palliation. Following treatment, symptom severity, octreotide dose, and tumor response were measured. Asymptomatic patients did not develop symptoms or require following treatment. Hepatic metastases remained stable (n=4) or decreased (n=19) in 23 patients (95.8%). Mean pretreatment Symptom Severity Scores (3.8+/-0.2), decreased to 1.4+/-0.1 post-treatment (P<0.00001), with 64.3% of patients becoming asymptomatic. Mean pretreatment octreotide dosages (679.6±73.0 μg/d), decreased to 262.9±92.7 μg/d (P=0.0024) post-treatment, with 46.2% of patients discontinuing octreotide. There were no treatment-related serious complications or deaths. This study demonstrates that Lipiodol/Gelfoam HAE produces excellent control of malignant carcinoid syndrome, allowing patients to decrease or eliminate use of octreotide, while controlling hepatic tumor burden.
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