Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 13, Issue 7, Pages 275-276Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S1043-2760(02)00640-9
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The hepatic conversion of cholesterol to bile acids is an important mechanism for the elimination of excess dietary cholesterol. Bile acid biosynthesis and transport are regulated by the farnesoid X receptor (FXR), a member of the of nuclear hormone receptor gene superfamily. Thus, therapeutic strategies that target FXR represent a promising new approach for the treatment of hypercholesterolemia. Recent studies have provided new evidence in support of the potential for FXR ligands as antihypercholesterolemic agents.
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