Journal
MOLECULAR IMMUNOLOGY
Volume 38, Issue 16-18, Pages 1229-1233Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0161-5890(02)00068-8
Keywords
mast cells; protein tyrosine kinase Syk; signal transduction; Fe epsilon RI; histamine release
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The tyrosine kinase Syk is essential for signaling from FcepsilonRI in mast cells. The Src homology domain mediated binding of Syk to the phosphorylated immunoreceptor tyrosine-based motif (ITAM) of the receptor subunits results in a conformational change and activation. Studies in Syk deficient mast cells have defined the pathways that are activated upstream and downstream of Syk and have demonstrated the functional importance of the linker region of Syk in signaling in mast cells. Published by Elsevier Science Ltd.
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