Journal
INFECTION AND IMMUNITY
Volume 70, Issue 9, Pages 5287-5289Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.70.9.5287-5289.2002
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Funding
- NHLBI NIH HHS [HL07638, HL61234, T32 HL007638, P50 HL061234] Funding Source: Medline
- NIAID NIH HHS [R37 AI024616, R01 AI024616, AI24616, AI07511, T32 AI007511, N01AI65298, AI65298, R56 AI024616] Funding Source: Medline
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Nontypeable Haemophilus influenzae (NTHI) lipooligosaccharide htrB mutants exhibited greater than 45-fold-increased sensitivity to human beta-defensin 2 (HBD-2) compared to the wild type. Complementation by htrB in trans to acylation competence reversed this increased sensitivity. In contrast, NTHI was more susceptible to HBD-3 and showed no changes in sensitivity as a result of lipooligosaccharide mutations in oligosaccharide and lipid A biosynthesis genes.
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