Journal
MICROBES AND INFECTION
Volume 4, Issue 11, Pages 1193-1202Publisher
ELSEVIER
DOI: 10.1016/S1286-4579(02)01645-3
Keywords
thalidomide; leprosy; erythema nodosum leprosum; type 2 reaction
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Leprosy is a chronic infection of the skin and nerves caused by Mycobacterium leprae. Erythema nodosum leprosum (ENL) is a reactive state in lepromatous leprosy. Thalidomide has been used to treat ENL since the 1960s. One of its mechanisms of action is anti-inflammatory through selective inhibition of the pro-inflammatory cytokine TNF-alpha produced by monocytes. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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