Secular trend of hospital-acquired candidemia among intensive care unit patients in the United States during 1989-1999

We describe the annual incidence of primary bloodstream infection (BSI) associated with Candida albicans and common non-albicans species of Candida among patients in intensive care units that participated in the National Nosocomial Infections Surveillance system from 1 January 1989 through 31 December 1999. During the study period, there was a significant decrease in the incidence of C. albicans BSI (P < .001) and a significant increase in the incidence of Candida glabrata BSI (P = .05).