Journal
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
Volume 283, Issue 3, Pages H1244-H1252Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpheart.01109.2001
Keywords
arrhythmia; mapping; pacing; pathology; activation cycle length
Funding
- NHLBI NIH HHS [HL-66389, P50-HL-52319] Funding Source: Medline
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Repetitive rapid activities are present in the pulmonary veins (PVs) in dogs with pacing-induced sustained atrial fibrillation (AF). The mechanisms are unclear. We induced sustained (>48 h) AF by rapidly pacing the left atrium (LA) in six dogs. High-density computerized mapping was done in the PVs and atria. Results show repetitive focal activations in all dogs and in 12 of 18 mapped PVs. Activation originated from the middle of the PV and then propagated to the LA and distal PV with conduction blocks. The right atrium (RA) was usually activated by a single large wavefront. Mean AF cycle length in the PVs (left superior, 82+/-6 ms; left inferior, 83+/-6 ms; right inferior, 83+/-4 ms) and LA posterior wall (87+/-5 ms) were significantly (P<0.05) shorter than those in the LA anterior wall (92±4 ms) and RA (107±5 ms). PVs in normal dogs did not have focal activations during induced AF. No reentrant wavefronts were demonstrated in the PVs. We conclude that nonreentrant focal activations are present in the PVs in a canine model of pacing-induced sustained AF.
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