Synthesis of 2-amino-6-(2-[18F]fluoro-pyridine-4-ylmethoxy)-9-(octyl-β-D-glucosyl)-purine:: a novel radioligand for positron emission tomography studies of the O6-methylguanine-DNA methyltransferase (MGMT) status of tumour tissue

The synthesis of the novel glucose conjugated O-6-methylguanine-DNA methyltransferase (MGMT) inhibitor 2-amino-6-(2-[F-18]fluoro-pyridine-4-ylmethoxy)-9-(octyl-alpha-D-glucosyl)-purine is reported. This compound might serve as a radiotracer for the determination of the MGMT status of tumour tissue. (C) 2002 Elsevier Science Ltd. All rights reserved.