4.4 Article

A new efficient synthesis of ortho-cyanoarenes via directed lithiation followed by electrophilic cyanation

Journal

TETRAHEDRON LETTERS
Volume 43, Issue 36, Pages 6403-6404

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(02)01382-5

Keywords

directed lithiation; electrophilic cyanation; phenyl cyanate; nitriles

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A one-pot procedure for the conversion of mono-substituted arenes into the ortho-cyano derivatives was accomplished through directed lithiation followed by electrophilic cyanation with phenyl cyanate. (C) 2002 Elsevier Science Ltd. All rights reserved.

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