Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1592, Issue 1, Pages 63-77Publisher
ELSEVIER
DOI: 10.1016/S0167-4889(02)00265-3
Keywords
mitochondrion; protein import; processing peptidase; presequence
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Funding
- NIA NIH HHS [AG15709] Funding Source: Medline
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Three peptidases are responsible for the proteolytic processing of both nuclearly and mitochondrially encoded precursor polypeptides targeted to the various subcompartments of the mitochondria. Mitochondrial processing peptidase (MPP) cleaves the vast majority of mitochondrial proteins, while inner membrane peptidase (IMP) and mitochondrial intermediate peptidase (MIP) process specific subsets of precursor polypeptides. All three enzymes are structurally and functionally conserved across species, and their human homologues begin to be recognized as potential players in mitochondrial disease. (C) 2002 Elsevier Science B.V. All rights reserved.
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