Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 99, Issue 18, Pages 11760-11765Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.192285999
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- NIDDK NIH HHS [R37 DK050107, R01 DK055700, R01 DK050107, DK50107, DK55700] Funding Source: Medline
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The hematopoietic transcription factor GATA-1 regulates erythropoiesis and beta-globin expression. Although consensus GATA-1 binding sites exist throughout the murine beta-globin locus, we found that GATA-1 discriminates among these sites in vivo. Conditional expression of GATA-1 in GATA-1-null cells recapitulated the occupancy pattern. GATA-1 induced RNA polymerase 11 (pol 11) recruitment to subregions of the locus control region and to the beta-globin promoters. The hematopoietic factor NF-E2 cooperated with GATA-1 to recruit pol 11 to the promoters. We propose that only when GATA-1 attracts pol 11 to the locus control region can pol 11 access the promoter in a NF-E2-dependent manner.
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