Journal
BRAIN RESEARCH
Volume 948, Issue 1-2, Pages 155-158Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(02)03055-X
Keywords
prefrontal cortex; in vivo microdialysis; dopamine; gamma-aminobutyric acid; glutamate; cannabinoid
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Cannabinoid modulation of prefrontal cortex and hippocampus neuronal functioning has been correlated to the disruptive action of marijuana on memory tasks. This study investigates the effects of Delta(9)-tetrahydrocannabinol (Delta(9)-THC) on dopamine, glutamate and GABA levels in vivo by brain microdialysis in the prefrontal cortex. Delta(9)-THC (1 mg/kg, i.v.) significantly increased extracellular dopamine and glutamate levels and decreased GABA levels. These effects were prevented by the cannabinoid antagonist SR141716A (1 mg/kg, i.v.), which per se was ineffective. These results suggest that Delta(9)-THC disrupt the normal interplay between neuro transmitters in this area and may bear relevance in understanding neuronal mechanisms underlying cannabinoid-induced cognitive deficits. (C) 2002 Elsevier Science B.V. All rights reserved.
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