Journal
BRAIN RESEARCH
Volume 948, Issue 1-2, Pages 145-148Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(02)03045-7
Keywords
agouti-related protein; alpha-melanocyte-stimulating hormone; central nervous system; melanocortin-4 receptor; sympathetic nervous system
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Intracerebroventricular injection of alpha-melanocyte-stimulating hormone (alpha-MSH) elicited increases in arterial pressure and renal sympathetic nerve activity in conscious rabbits. Pretreatment with intracerebroventricular injection of agouti-related protein, an endogenous melanocortin-3 and 4 receptor antagonist, prevented cardiovascular and sympathetic responses to alpha-MSH. Pretreatment with intraccrebroventricular injection of JKC-363, a synthetic specific melanocortin-4 receptor antagonist, also prevented cardiovascular and sympathetic responses to alpha-MSH In contrast, intravenous alpha-MSH (1 nmol) failed to cause any cardiovascular responses. These results suggest that intracerebroventricularly administered alpha-MSH acts at the melanocortin-4 receptor in the brain and activates sympathetic outflow, resulting in an increase in arterial pressure. (C) 2002 Elsevier Science B.V. All rights reserved.
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