Antifungal cyclopeptides from Halobacillus litoralis YS3106 of marine origin

Three new cyclopeptides, including halolitoralin A (a cyclic hexapeptide), halolitoralin B mid C (two cyclic tetrapeptides), together with three known cyclic dipeptides, cyclo(Pro-Val), cyclo(Pro-Leu) and cyclo(Ile-Val) were isolated from the ferment broth of a marine sediment-derived Halobacillus litoralis YS3106. The cyclopeptides show surprisingly simple architectures with highly repeated residue units, which showed moderate antifungal and weak antitumor activities in vitro. (C) 2002 Elsevier Science Ltd. All rights reserved.