Journal
FEBS LETTERS
Volume 527, Issue 1-3, Pages 5-9Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(02)03167-8
Keywords
dehydroascorbic acid; ascorbic acid; transport; oxidative stress; inflammation; sepsis; diabetes
Ask authors/readers for more resources
Dehydroascorbic acid (DHA) is abundant in the human diet and also is generated from vitamin C (ascorbic acid, AA) in the lumen of the gastrointestinal tract. DHA is absorbed from the lumen of the small intestine and reduced to AA, which subsequently circulates in the blood. Utilization of AA as an antioxidant and enzyme cofactor causes its oxidation to DHA in extracellular fluid and cells. DHA has an important role in many cell types because it can be used to regenerate AA. Both physiological (e.g. insulin, insulin-like growth factor 1, cyclic AMP) and pathological (e.g. oxidative stress, diabetes, sepsis) factors alter the transport and metabolic mechanisms responsible for this DHA recycling. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available