Journal
FEBS LETTERS
Volume 527, Issue 1-3, Pages 303-308Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(02)03246-5
Keywords
natively unfolded; mitosis; circular dichroism; nuclear magnetic resonance; cyclin B; securin
Funding
- NIGMS NIH HHS [GM 57536] Funding Source: Medline
Ask authors/readers for more resources
The proteins securin and cyclin B are destroyed in mitosis by the ubiquitin/proteasome system. This destruction is important to mitotic progression. The N-terminal regions of these proteins contain the sequence features recognized by the ubiquitination system. We have demonstrated using circular dichroism and 1-D and 2-D nuclear magnetic resonance that these rather substantial regions are natively unfolded. Based on these findings, we propose a model that helps to explain previously enigmatic observations. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available