Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 451, Issue 2, Pages 111-118Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-2999(02)02192-1
Keywords
xanthine oxidase; flavonoid; structure-function relationship; inhibition; IC50
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The flavonoid family shows a high potential for inhibition of xanthine oxidase. Currently, more than 4000 flavonoids are known. The data of this study indicate that a planar structure is necessary for high inhibitory activity towards xanthine oxidase. Moreover, the contribution of a hydroxyl conjugate turns out to be a constant factor when the natural logarithm of IC50 values is taken. This finding allows us to accurately predict the IC50 value of any given hydroxyl group added to the basic flavone structure towards xanthine oxidase. This new method may provide an important research tool for elucidating the role that flavonoids may have in radical related diseases. (C) 2002 Elsevier Science B.V. All rights reserved.
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